PE-22-28 Nasal Spray 10 mg · 10 ML

PE-22-28 is a synthetic 7-amino-acid peptide derived from spadin (PE 12-28), itself a fragment of the neurotensin pro-sortilin propeptide. It is studied for its selective inhibition of the TREK-1 (KCNK2) potassium channel — a target implicated in depression, neurogenesis, and neuroprotective signaling pathways.

Product Highlights

• Each vial contains 10 mL solution (~100 sprays)

• Each spray delivers 0.1 mL = 100 mcg PE-22-28

• Total PE-22-28 Content: 10 mg per vial

• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose

• Unlike many other nasal sprays, this formula avoids irritation and dryness

• Packaged in Class A, lead-free pharmaceutical glass bottles

• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use

Description

PE-22-28 is explored for selective TREK-1 channel inhibition (IC₅₀ ≈ 0.12 nM), with research interest in mood regulation, hippocampal neurogenesis, neuroprotection in ischemia models, and synaptic plasticity.

Benefits

• TREK-1 channel inhibition — studied as a potent and selective KCNK2 blocker

• Antidepressant signaling — explored in forced-swim and tail-suspension behavioral models

• Hippocampal neurogenesis — investigated for increases in newborn neuron survival

• Neuroprotection — examined in cerebral ischemia and stroke models for reduced infarct volume

• Synaptogenesis — linked to synaptic protein expression and plasticity research

• Pancreatic β-cell survival — explored in islet apoptosis and diabetes models

Localized Effects with Nasal Spray

• Rapid uptake through the nasal mucosa

• Direct olfactory and trigeminal nerve pathway access to the central nervous system

• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability

• Particularly relevant for PE-22-28 given its central TREK-1 targets in brain tissue

• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness

What Researchers Use It For

• TREK-1 / KCNK2 channel pharmacology and electrophysiology studies

• Depression and anxiety behavioral model research (FST, TST, NSF)

• Hippocampal neurogenesis and BrdU/doublecortin labeling endpoints

• Stroke and cerebral ischemia neuroprotection in rodent MCAO models

• Synaptic plasticity, LTP, and synaptogenesis pathway research

• β-cell survival and CREB signaling investigations

Identity & Specs

• Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (7 amino acids; H-GVSWGLR-OH)

• Formula / M.W.: C₃₅H₅₅N₁₁O₉, ~773.89 g/mol

• CAS: 1801959-12-5

• Form: Sterile nasal spray solution

• Net per vial: 10 mL (~100 sprays)

• Total Content: 10 mg PE-22-28 per vial

• Concentration: 1 mg/mL (100 mcg per 0.1 mL spray)

• Purity: ≥99% (HPLC)

• Identity: MS-verified (per COA)

• Storage: Refrigerate 2–8 °C, protect from light

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.