J-147 · 10MG

J-147 is a small-molecule curcumin derivative developed at the Salk Institute as a neuroprotective and neurotrophic research compound. Originally synthesized as a hybrid between curcumin and cyclohexyl-bisphenol A and refined from the CNB-001 scaffold, J-147 has been studied in preclinical models for its effects on mitochondrial function, synaptic signaling, and neuronal survival. Reported research targets include the mitochondrial ATP synthase α-subunit, monoamine oxidase B (MAO-B), and the dopamine transporter, with documented activity against glutamate-induced excitotoxicity and amyloid-β toxicity in cortical neuron cultures.

Benefits (Research Focus)

• Studied as a curcumin-derived neuroprotective and neurotrophic compound

• Investigated for binding to mitochondrial ATP synthase α-subunit

• Explored for MAO-B inhibition and dopamine transporter activity

• Examined in transgenic Alzheimer's models and SAMP8 accelerated-aging mice

• Researched for cognitive performance and synaptic plasticity endpoints

What Researchers Look At

• Neuronal survival under glutamate and amyloid-β toxicity (EC₅₀ ≈ 0.1–0.3 µM)

• Long-term potentiation (LTP) and synaptic gene expression panels

• Mitochondrial membrane potential and ATP production endpoints

• Egr3, NGF, and BDNF transcriptional response

• Cognitive endpoints in aged AD and accelerated-aging mouse models

Quick Specs

• Form: Gelatin capsule

• Strength: 10 mg/capsule

• Quantity: 30 capsules per bottle

• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler

• Storage: Store in a cool, dry, dark place

Identity Basics

• Compound: J-147

• Chemical Name: N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide

• Chemical Formula: C₁₈H₁₇F₃N₂O₂

• Molecular Weight: 350.34 g/mol

• CAS: 1146963-51-0

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.