9-Me-BC · 20MG

9-Me-BC (9-methyl-β-carboline) is a small-molecule alkaloid derivative of the β-carboline scaffold, studied for its unique combination of neurogenic, dopaminergic, and anti-inflammatory effects in central nervous system research models. Originally characterized by the Polanski group at Heinrich-Heine-Universität Düsseldorf, 9-Me-BC has been investigated in cell-culture and rodent models for promoting dopamine neuron differentiation, upregulating BDNF and GDNF expression, increasing dendritic spine density, and protecting against neuroinflammation in MPTP and LPS-induced models of Parkinson's-like neurodegeneration. The compound is small (~182 Da), lipophilic, and crosses the blood-brain barrier readily after oral administration, placing it among the most pharmacologically accessible neurogenic compounds in current research catalogs.

Benefits (Research Focus)

• Studied for dopaminergic neuron differentiation and neurogenesis in midbrain models

• Investigated for BDNF and GDNF upregulation in cortical and hippocampal cultures

• Explored for dendritic spine density and synaptic complexity enhancement

• Examined for anti-inflammatory effects in microglial activation models

• Researched for neuroprotection in MPTP and LPS-induced Parkinson's-like models

What Researchers Look At

• Tyrosine hydroxylase expression and dopaminergic neuron survival

• BDNF, GDNF, and CREB pathway transcriptional response

• Dendritic spine density, synaptic protein expression, and LTP endpoints

• Microglial activation markers (Iba1, TNF-α, IL-6) and neuroinflammation profiles

• Cognitive performance and locomotor activity in aged and neurodegeneration models

Quick Specs

• Form: Gelatin capsule

• Strength: 20 mg/capsule

• Quantity: 30 capsules per bottle

• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler

• Storage: Store in a cool, dry, dark place

Identity Basics

• Compound: 9-Me-BC (9-Methyl-β-carboline)

• Synonyms: 9-Methyl-9H-pyrido[3,4-b]indole; 9-MBC

• Class: β-carboline alkaloid derivative; neurogenic small molecule

• Chemical Formula: C₁₂H₁₀N₂

• Molecular Weight: 182.23 g/mol

• CAS: 2521-07-5

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.