This product is intended for laboratory research use only.
Not for human or veterinary use.
Not approved for diagnostic, therapeutic, or medical applications.
Handle using appropriate laboratory safety procedures and personal protective equipment.
PE-22-28 is a synthetic 7-amino-acid peptide derived from spadin (PE 12-28), itself a fragment of the neurotensin pro-sortilin propeptide. It is studied for its selective inhibition of the TREK-1 (KCNK2) potassium channel — a target implicated in depression, neurogenesis, and neuroprotective signaling pathways.
• Each vial contains 10 mL solution (~100 sprays)
• Each spray delivers 0.1 mL = 100 mcg PE-22-28
• Total PE-22-28 Content: 10 mg per vial
• Specialized pharmaceutical-grade nasal solution — designed for comfort and ease on the nose
• Unlike many other nasal sprays, this formula avoids irritation and dryness
• Packaged in Class A, lead-free pharmaceutical glass bottles
• Tamper/Child-Proof Cap + Orifice Reducer for integrity, sterility, and ease of use
PE-22-28 is explored for selective TREK-1 channel inhibition (IC₅₀ ≈ 0.12 nM), with research interest in mood regulation, hippocampal neurogenesis, neuroprotection in ischemia models, and synaptic plasticity.
• TREK-1 channel inhibition — studied as a potent and selective KCNK2 blocker
• Antidepressant signaling — explored in forced-swim and tail-suspension behavioral models
• Hippocampal neurogenesis — investigated for increases in newborn neuron survival
• Neuroprotection — examined in cerebral ischemia and stroke models for reduced infarct volume
• Synaptogenesis — linked to synaptic protein expression and plasticity research
• Pancreatic β-cell survival — explored in islet apoptosis and diabetes models
• Rapid uptake through the nasal mucosa
• Direct olfactory and trigeminal nerve pathway access to the central nervous system
• Bypasses first-pass hepatic metabolism that limits oral peptide bioavailability
• Particularly relevant for PE-22-28 given its central TREK-1 targets in brain tissue
• Formulated with a specialized isotonic nasal vehicle to minimize irritation and dryness
• TREK-1 / KCNK2 channel pharmacology and electrophysiology studies
• Depression and anxiety behavioral model research (FST, TST, NSF)
• Hippocampal neurogenesis and BrdU/doublecortin labeling endpoints
• Stroke and cerebral ischemia neuroprotection in rodent MCAO models
• Synaptic plasticity, LTP, and synaptogenesis pathway research
• β-cell survival and CREB signaling investigations
• Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg (7 amino acids; H-GVSWGLR-OH)
• Formula / M.W.: C₃₅H₅₅N₁₁O₉, ~773.89 g/mol
• CAS: 1801959-12-5
• Form: Sterile nasal spray solution
• Net per vial: 10 mL (~100 sprays)
• Total Content: 10 mg PE-22-28 per vial
• Concentration: 1 mg/mL (100 mcg per 0.1 mL spray)
• Purity: ≥99% (HPLC)
• Identity: MS-verified (per COA)
• Storage: Refrigerate 2–8 °C, protect from light
⚠️ Disclaimer
Every batch ships with a matching Certificate of Analysis. The batch number printed on your vial corresponds directly to its published certificate. Verify any batch on our Testing & COAs page.
Orders placed before 5 PM ET ship the same business day via Xpresspost. Most Canadian addresses receive delivery within 1–2 business days. Free shipping applies automatically on orders over $200.
Store refrigerated at 2–8 °C, protected from light. For laboratory research use only — not for human consumption.
