MK-677 · 10MG

MK-677 (Ibutamoren) is a synthetic non-peptide small molecule developed by Merck as an orally active growth hormone secretagogue. The compound is studied as a selective agonist of the ghrelin receptor (GHS-R1a), mimicking the action of endogenous ghrelin at the pituitary and hypothalamus to stimulate pulsatile growth hormone (GH) release. Unlike peptide-class GH secretagogues that require injection, MK-677 is orally bioavailable with a half-life of approximately 24 hours, supporting once-daily research protocols. Published preclinical and clinical research has examined the compound's effects on GH and IGF-1 dynamics, body composition, bone mineral density, sleep architecture, and appetite regulation, with reported pharmacology that activates GH release without significantly affecting cortisol, prolactin, ACTH, or thyroid hormone levels.

Benefits (Research Focus)

• Studied as a selective ghrelin / GHS-R1a receptor agonist

• Investigated for pulsatile growth hormone (GH) release without exogenous GH administration

• Explored for downstream IGF-1 signaling and somatotropic axis activation

• Examined for body composition, lean mass, and adiposity endpoints in aged models

• Researched for bone mineral density, sleep architecture, and appetite regulation pathways

What Researchers Look At

• Plasma GH and IGF-1 dynamics following oral administration

• Pulsatile GH release patterns over 24-hour cycles

• Body composition endpoints (DEXA, fat mass, lean mass) in aged or sarcopenic models

• Cortisol, prolactin, ACTH, and aldosterone selectivity profiling

• Slow-wave sleep duration and REM sleep architecture in sleep research

Quick Specs

• Form: Gelatin capsule

• Strength: 10 mg / capsule

• Quantity: 30 capsules per bottle

• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler

• Purity: ≥99%

• Storage: Store in a cool, dry, dark place

Identity Basics

• Compound: MK-677 (Ibutamoren)

• Synonyms: Ibutamoren mesylate; MK-0677; L-163,191

• Class: Non-peptide ghrelin receptor (GHS-R1a) agonist; oral growth hormone secretagogue

• Chemical Formula: C₂₇H₃₆N₄O₅S (free base)

• Molecular Weight: 528.66 g/mol (free base); 624.77 g/mol (mesylate salt)

• CAS: 159634-47-6 (free base); 159752-10-0 (mesylate salt)

⚠️ Disclaimer

• This product is intended for laboratory research use only.

• Not for human or veterinary use.

• Not approved for diagnostic, therapeutic, or medical applications.

• Handle using appropriate laboratory safety procedures and personal protective equipment.