Humanin · 10MG

Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 16S ribosomal RNA (MT-RNR2) gene, discovered in 2001 by the Hashimoto group while screening cDNA libraries from surviving neurons of Alzheimer's disease patients. Humanin is one of a small family of bioactive peptides encoded directly within mitochondrial DNA, alongside MOTS-c and the SHLP peptide family. It is studied in preclinical research as a cytoprotective and neuroprotective signaling peptide, with reported effects mediated through binding to multiple receptor systems including the formyl peptide receptor 2 (FPR2), the gp130/CNTFR/WSX-1 trimeric complex, and the IGFBP-3 / Bax pathway. Humanin has been investigated in cell culture and rodent research models of neurodegeneration, oxidative stress, ischemia, and metabolic dysfunction, with research interest in mitochondrial signaling, apoptosis modulation, and age-related cellular decline.

Benefits (Research Focus)

• Mitochondrial-derived signaling — studied as a 16S rRNA-encoded bioactive peptide in the MDP family

• Cytoprotective research — investigated for cellular survival pathways under oxidative stress conditions

• Neuroprotection — explored in preclinical models of neurodegeneration and ischemia

• Apoptosis modulation — examined for interaction with Bax and pro-apoptotic signaling pathways

• Metabolic signaling — researched for connections to IGF-1, IGFBP-3, and AMPK pathway endpoints

What Researchers Look At

• FPR2 and gp130/CNTFR/WSX-1 receptor complex binding

• Bax translocation, mitochondrial outer membrane permeabilization, and apoptosis markers

• Cytoprotective endpoints in neuronal and cardiac cell models

• IGFBP-3 binding affinity and downstream IGF-1 axis modulation

• Comparative MDP pharmacology versus MOTS-c, SHLP1-6, and other mitochondrial-derived peptides

Quick Specs

• Form: Lyophilized white powder

• Net Peptide Content: 10 mg per vial

• Quantity: 1 vial

• Appearance: White to off-white lyophilizate

• Reconstitution: Bacteriostatic or sterile water (added by the end researcher)

• Purity: ≥99% by HPLC

• Identity: MS-verified (per COA)

• Storage: Protect from light

Identity Basics

• Compound: Humanin

• Synonyms: HN; mitochondrial-derived neuroprotective peptide; MT-RNR2-encoded peptide

• Class: Mitochondrial-derived peptide (MDP); 16S rRNA-encoded; 24 amino acids

• Sequence: Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala (MAPRGFSCLLLLTSEIDLPVKRRA)

• Formula / M.W.: C₁₄₀H₂₃₉N₄₁O₄₅S, ~2687.78 g/mol (per COA; verify exact MW against batch spec)

• CAS: 831115-76-1

⚠️ Disclaimer

• This product is intended for laboratory research use only.
• Not for human or veterinary use.
• Not approved for diagnostic, therapeutic, or medical applications.
• Handle using appropriate laboratory safety procedures and personal protective equipment.

COA Verification Notice: Even if the vial label or product image states a certain concentration, always go by the COA for the true verified value. We reference the COA to determine the verified concentration and purity of each product, regardless of what the label or product image indicates.

Janoshik COA — Third-Party Testing

• Humanin VPeptide Canada — January 12, 2026