Epithalon · 3MG

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide bioregulator with the amino acid sequence Ala-Glu-Asp-Gly (AEDG), developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology. The peptide was originally derived from the protein structure of Epithalamin, a pineal gland extract studied extensively in Russian gerontology research since the 1960s. Epithalon is investigated as a Khavinson-class short peptide with proposed epigenetic regulatory activity, including studies reporting telomerase reactivation, telomere elongation in cell-culture models, and modulation of melatonin and serotonin biosynthesis in the pineal gland. Research interest extends to circadian rhythm regulation, age-associated gene expression patterns, antioxidant defense pathways, and longevity-related endpoints in rodent and human aging studies. Its small molecular weight (~390 Da) supports cellular uptake and is reported to enable direct DNA / chromatin interaction at gene promoter regions, consistent with the broader Khavinson bioregulator hypothesis.

Benefits (Research Focus)

• Studied as a Khavinson-class tetrapeptide bioregulator for epigenetic gene-expression modulation

• Investigated for telomerase activity and telomere length in cell-culture models

• Explored for pineal gland regulation and melatonin / serotonin biosynthesis

• Examined for circadian rhythm research and sleep-wake cycle endpoints in aged models

• Researched for geroprotective effects and age-associated gene expression patterns

What Researchers Look At

• Telomerase enzymatic activity and telomere length in human somatic cell cultures

• Pineal gland melatonin synthesis enzymes (AANAT, ASMT) and circulating melatonin

• AACG-motif binding affinity and promoter region transcriptional modulation

• Antioxidant defense markers (SOD, catalase, glutathione peroxidase) in aged tissues

• Comparative bioregulator pharmacology versus other Khavinson peptides (Pinealon, Cortagen, Vesugen)

Quick Specs

• Form: Gelatin capsule

• Strength: 3 mg / capsule

• Quantity: 30 capsules per bottle

• Excipient: Microcrystalline cellulose (MCC) — pharmaceutical-grade filler

• Purity: ≥99%

• Storage: Store in a cool, dry, dark place

Identity Basics

• Compound: Epithalon

• Synonyms: Epitalon; AEDG; Epithalamin tetrapeptide; H-Ala-Glu-Asp-Gly-OH

• Class: Khavinson-class tetrapeptide bioregulator; pineal-derived short peptide

• Sequence: Ala-Glu-Asp-Gly (AEDG)

• Chemical Formula: C₁₄H₂₂N₄O₈

• Molecular Weight: 390.35 g/mol

• CAS: 307297-39-8

⚠️ Disclaimer

• This product is intended for laboratory research use only.

• Not for human or veterinary use.

• Not approved for diagnostic, therapeutic, or medical applications.

• Handle using appropriate laboratory safety procedures and personal protective equipment.